Codeine may boost the neuromuscular blocking motion of skeletal muscle mass relaxants and create an elevated degree of respiratory depression.

A Health care Specialist really should be consulted ahead of getting any drug, altering any food plan or commencing or discontinuing any system of treatment.

Promethazine with Codeine Oral Option isn't advised to be used in Expecting Girls [see Use in Particular Populations (eight.one)]. Extended usage of Promethazine with Codeine Oral Answer through pregnancy can result in neonatal opioid withdrawal syndrome, which can be life-threatening if not recognized and treated, and demands management In keeping with protocols designed by neonatology authorities.

Discontinuation of a concomitantly applied cytochrome P450 2D6 inhibitor may possibly end in a decrease in codeine plasma focus and an increase in Lively metabolite morphine plasma focus which could enhance or prolong adverse reactions and could trigger perhaps deadly respiratory depression.

Such as, several described circumstances of death transpired inside the article-operative interval next tonsillectomy and/or adenoidectomy, and many of the kids experienced proof of staying extremely-speedy metabolizers of codeine. Furthermore, children with obstructive rest apnea who're addressed with codeine for publish-tonsillectomy and/or adenoidectomy pain can be notably delicate to its respiratory depressant result. Due to hazard of life-threatening respiratory melancholy and death:

Promethazine is a phenothiazine derivative, which differs structurally from the antipsychotic phenothiazines from the existence of the branched side chain and no ring substitution.

If another person has overdosed and it has really serious signs for example passing out or difficulties breathing, simply call 911. Or else, call a poison Regulate center right away.

Assess Just about every affected individual's chance prior to prescribing Promethazine with Codeine Oral Resolution, prescribe Promethazine with Codeine Oral Option for that shortest period that is in keeping with person affected person therapy goals, keep an eye on all sufferers often for the event of addition or abuse, and refill only following reevaluation of the necessity for ongoing treatment method. [see Warnings and Safeguards (five.1)]

Utilizing narcotics for a long period could cause severe constipation. To forestall this, your health practitioner could immediate you to definitely get laxatives, drink many fluids, or improve the amount of fiber in your diet.

Go through the Medication Information supplied by your pharmacist Before you begin using promethazine/phenylephrine/codeine and each time you get a refill. In case you have any issues, talk to your health practitioner or pharmacist.

The dose of the medication might be diverse for different sufferers. Comply with your health care provider's orders or maybe the Instructions within the label. The following data consists of only the typical doses of the drugs. When your dose is different, never change it Except your physician tells you to take action.

Codeine Codeine is definitely an opioid agonist comparatively selective to the mu-opioid receptor, but having a Substantially weaker affinity than morphine. The analgesic and antitussive Qualities of codeine are already speculated to come from its conversion to morphine.

Other Unintended effects not listed can also arise in a few sufferers. In the event you discover some other consequences, Look at with all your Health care Experienced.

Speak with your doctor Should you have any questions on using codeine or about how Promethazine codeine syrup this medication may possibly have an affect on your little one.